Human Whole Body Pharmacokinetic Minimal Model for the Liver Specific Contrast Agent Gd-EOB-DTPA LIU-IMH/RV-A- -11/001- -SE
نویسندگان
چکیده
منابع مشابه
Focal hepatic lesions in Gd-EOB-DTPA enhanced MRI: the atlas
OBJECTIVE This article reviews the different technical aspects and pitfalls of gadolinium (Gd)-ethoxibenzyl (EOB)-diethylenetriamine pentaacetic acid (DTPA) and the advantages of the hepatocellular phase (HCP) and defines its specific imaging features of liver lesions. BACKGROUND Gd-EOB-DTPA is a contrast agent with combined properties of a conventional non-specific extracellular and a hepato...
متن کاملGd-EOB-DTPA (EovistO), A Liver Specific Contrast Agent For MRI: Results of a Placebo Controlled, Double Blind Dose Ranging Study in Patients with Focal Hepatic Lesions
The objective of this study was to determine the diagnostic efficacy and safety of Gd-EOB-DTPA (Eovista) at 4 doses (3.0; 6.0; 12.5 and 25 pmol Gd-EOB-DTPNkg BW [body weight]) as compared to placebo (0.9% salinc) in patients with known focal liver lesion(s) A total of 171 received contrast medium injection or placebo (0.9% salinc) Thirty five patients received placebo, 33 patients receivcd 3, 3...
متن کاملMRI-based estimation of liver function: Gd-EOB-DTPA-enhanced T1 relaxometry of 3T vs. the MELD score
Gd-EOB-DTPA is a hepatocyte-specific MRI contrast agent. Due to its hepatocyte-specific uptake and paramagnetic properties, functioning areas of the liver exhibit shortening of the T1 relaxation time. We report the potential use of T1 relaxometry of the liver with Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) for estimating the liver function as expressed by the MELD score. 3 T MRI rela...
متن کاملDynamic-contrast-enhanced magnetic resonance imaging of cirrhotic liver parenchyma: A comparison between gadolinium-diethylenetriamine pentaacetic acid and gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid.
BACKGROUND The newly developed magnetic-resonance-imaging (MRI) hepatocyte-specific contrast agent, gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA), has different excretion pathways from the conventional MRI contrast agent, gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA). In this study, we compare the enhancement effect of the liver and renal parenchyma betwee...
متن کاملGd-EOB-DTPA-enhanced MRI for evaluation of liver function: Comparison between signal-intensity-based indices and T1 relaxometry
Gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) is a paramagnetic hepatobiliary magnetic resonance (MR) contrast agent. Due to its OATP1B1/B3-dependent hepatocyte-specific uptake and paramagnetic properties increasing evidence has emerged to suggest that Gd-EOB-DTPA-enhanced MRI can be potentially used for evaluation of liver function. In this paper we compare the diagn...
متن کامل